H5142

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H5142

Sigma

 

20-Hydroxyecdysone

≥93% (HPLC), powder

Synonym:β-Ecdysone, Ecdysterone, Insect moulting hormone, Polypodine A, 2β,3β,14α,20β,22,25-Hexahydroxy-7-cholesten-6-one
CAS Number:5289-74-7
Linear Formula:C27H44O7
Molecular Weight:480.63
Beilstein Registry Number:1917578
MDL number:MFCD00036740
PubChem Substance ID:24895674

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Description

Biochem/physiol ActionsAn ecdysteroid hormone that plays a key role insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in molting and metamorphosis. It acts through a heterodimeric receptor comprising the ecdysone receptor and the ultraspiracle proteins (USP).

Properties

assay≥93% (HPLC)
formpowder
color white to off-white
solubilityalcohol: soluble
storage temp.−20°C

Safety

Personal Protective EquipmentEyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany2
RTECSFZ8060000

References

referenceBuszczak, M., and Segraves, W.A., Drosophila metamorphosis: the only way is USP? Curr. Biol. 8, R879-R882, (1998) Abstract
 Champlin, D.T., and Truman, J.W., Ecdysteroid control of cell proliferation during optic lobe neurogenesis in the moth Manduca sexta. Development 125, 269-277, (1998) Abstract
 Kraft, R., et al., The steroid hormone 20-hydroxyecdysone enhances neurite growth of Drosophila mushroom body neurons isolated during metamorphosis. J. Neurosci. 18, 8886-8899, (1998) Abstract
 Hodin, J., and Riddiford, L.M., The ecdysone receptor and ultraspiracle regulate the timing and progression of ovarian morphogenesis during Drosophila metamorphosis. Dev. Genes Evol. 208, 304-317, (1998) Abstract
 Jiang, C., et al., Steroid regulated programmed cell death during Drosophila metamorphosis. Development 124, 4673-4683, (1997) Abstract
 Baehrecke, E.H., Ecdysone signaling cascade and regulation of Drosophila metamorphosis. Arch. Insect Biochem. Physiol. 33, 231-244, (1996) Abstract
MerckMerck 13,3525